tag:blogger.com,1999:blog-52406095403588718932024-03-13T23:37:29.057-07:00Malaria: Causes, Symptoms and TreatmentsAnonymoushttp://www.blogger.com/profile/05896487553262689465noreply@blogger.comBlogger1125tag:blogger.com,1999:blog-5240609540358871893.post-27188387002080538572017-02-03T15:04:00.000-08:002017-02-03T15:04:41.519-08:00Malaria: Causes, Symptoms and Treatments - Medical News Today<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
<span style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; font-weight: 600; margin: 0px; padding: 0px;"><a href="http://antimalariatablets.blogspot.co.uk/" target="_blank">Malaria</a> is a life-threatening blood disease caused by parasites transmitted to humans through the bite of the <em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">Anopheles</em> mosquito. Once an infected mosquito bites a human and transmits the parasites, those parasites multiply in the host's liver before infecting and destroying red blood cells.</span></div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
The disease can be controlled and treated if diagnosed early on. Unfortunately, this is not possible in some areas of the world lacking in medical facilities, where malaria outbreaks can occur.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
Researchers are working hard on improving the prevention of malarial infection, early diagnosis and treatment, with just one malaria vaccine close to being licensed so far.</div>
<div class="contents_list" style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 15px; margin: 0px; padding: 0px;">
<div style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
<span style="box-sizing: border-box; font-weight: 700;">Contents of this article:</span></div>
<ol style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; counter-reset: li 0; line-height: 22px; list-style: square; margin: 20px 0px 30px 18px; padding: 0px 0px 0px 10px;">
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px 25px; padding: 0px;"><a href="http://antimalariatablets.blogspot.co.uk/">What is malaria? Causes and symptoms</a></li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px 25px; padding: 0px;"><a href="http://antimalariatablets.blogspot.co.uk/" target="_blank">Diagnosis, treatment and vaccines for malaria</a></li>
</ol>
</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
You will also see introductions at the end of some sections to any recent developments that have been covered by <em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">MNT</em>'s news stories. Also look out for links to information about related conditions.</div>
<div class="quick_facts" style="-webkit-print-color-adjust: exact; background: url("/structure/images/icons/knowledge_center_facts.png") 12px 13px / 26px 26px no-repeat rgb(222, 243, 231); border: 1px solid rgb(221, 221, 221); box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 15px; margin: 30px 0px 20px; padding: 0px 0px 5px;">
<div style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; font-size: 16px; line-height: 24px; padding: 8px 15px 8px 10px;">
<span class="quick_facts_title" style="-webkit-print-color-adjust: exact; border-bottom-color: rgb(59, 125, 97); border-bottom-style: solid; border-image: initial; border-left-color: initial; border-left-style: initial; border-right-color: initial; border-right-style: initial; border-top-color: initial; border-top-style: initial; border-width: 0px 0px 1px; box-sizing: border-box; display: block; font-size: 21px; letter-spacing: -1px; line-height: 28px; margin: 5px 0px 0px; padding: 0px 0px 10px 40px; text-shadow: rgb(255, 255, 255) 1px 1px 2px;">Fast facts on malaria</span></div>
<div style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; font-size: 16px; line-height: 24px; padding: 8px 15px 8px 10px;">
Here are some key points on malaria. More detail and supporting information is in the main article.</div>
<ul style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 22px; list-style: square; margin: 20px 0px 30px 18px; padding: 0px 0px 0px 10px;">
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px 15px 0px 24px; text-indent: -15px;">Malaria was first identified in 1880 as a disease caused by parasitic infection<span style="border: 0px; box-sizing: border-box; color: inherit; font-size: 10px; font-weight: 700; line-height: 0; margin: 0px; padding: 0px 2px 0px 1px; position: relative; top: -0.5em; vertical-align: baseline;">1</span></li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px 15px 0px 24px; text-indent: -15px;">The name of the disease comes from the Italian word mal'aria, meaning "bad air"</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px 15px 0px 24px; text-indent: -15px;">Malaria is transmitted to humans through bites by infected mosquitoes</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px 15px 0px 24px; text-indent: -15px;">The most common time for these mosquitoes to be active is between dusk and dawn</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px 15px 0px 24px; text-indent: -15px;">Worldwide, there were an estimated 198 million cases of malaria in 2013 and 584,000 deaths</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px 15px 0px 24px; text-indent: -15px;">Malaria occurs mostly in poor, tropical and subtropical areas of the world</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px 15px 0px 24px; text-indent: -15px;">Malaria was eliminated from the US in the early 1950s, but the mosquitos that carry and transmit the malaria parasite still remain, creating a constant risk of reintroduction</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px 15px 0px 24px; text-indent: -15px;">Reported malaria cases in the US reached a 40-year high of 1,925 in 2011</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px 15px 0px 24px; text-indent: -15px;">A malaria vaccine for humans is close to being approved for use in Europe</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px 15px 0px 24px; text-indent: -15px;">An estimated 3.4 billion people in 106 countries and territories are at risk of malaria - nearly half of the world's population<span style="border: 0px; box-sizing: border-box; color: inherit; font-size: 10px; font-weight: 700; line-height: 0; margin: 0px; padding: 0px 2px 0px 1px; position: relative; top: -0.5em; vertical-align: baseline;">10</span></li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px 15px 0px 24px; text-indent: -15px;">Annual funding for malaria control in 2013 was three times the amount spent in 2005, yet it represented only 53% of global funding needs<span style="border: 0px; box-sizing: border-box; color: inherit; font-size: 10px; font-weight: 700; line-height: 0; margin: 0px; padding: 0px 2px 0px 1px; position: relative; top: -0.5em; vertical-align: baseline;">2</span></li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px 15px 0px 24px; text-indent: -15px;">Malaria incidence rates are estimated to have fallen by 30% globally between 2000 and 2013 while estimated mortality rates fell by 47%</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px 15px 0px 24px; text-indent: -15px;">The World Health Organization (WHO) has set out to reduce all malaria cases and deaths by 90% by 2030.<span style="border: 0px; box-sizing: border-box; color: inherit; font-size: 10px; font-weight: 700; line-height: 0; margin: 0px; padding: 0px 2px 0px 1px; position: relative; top: -0.5em; vertical-align: baseline;">3</span></li>
</ul>
</div>
<h2 style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; clear: both; color: #111111; display: table-cell; font-family: Arial, Helvetica, sans-serif; font-size: 27px; letter-spacing: -1px; line-height: 36px; margin: 30px 0px 20px; padding: 20px 0px 10px; text-shadow: rgb(255, 255, 255) 1px 1px 2px;">
What is malaria?</h2>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
Derived from the Italian word for "bad air," it was originally thought swamp fumes in Rome were the cause of malaria, as outbreaks were a regular occurrence there.<span style="border: 0px; box-sizing: border-box; color: inherit; font-size: 10px; font-weight: 700; line-height: 0; margin: 0px; padding: 0px 2px 0px 1px; position: relative; top: -0.5em; vertical-align: baseline;">4</span></div>
<div class="photobox_right" style="-webkit-print-color-adjust: exact; background-color: white; border: 1px solid rgb(215, 232, 224); box-sizing: border-box; clear: right; color: #444444; float: right; font-family: Arial, Helvetica, sans-serif; font-size: 0.9em; line-height: 18px; margin: 10px 0px 20px 20px; max-width: 350px; min-width: 100px; outline: 0px; padding: 10px; text-align: center;">
<img alt="Malaria parasites invading the red blood cells." data-src="http://cdn1.medicalnewstoday.com/content/images/articles/150/150670/malaria-parasites-invade-the-red-blood-cells-multiplying-quickly.jpg" src="https://cdn1.medicalnewstoday.com/content/images/articles/150/150670/malaria-parasites-invade-the-red-blood-cells-multiplying-quickly.jpg" style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; float: none; height: auto; margin: 0px auto 5px; max-width: 100%; outline: rgb(245, 245, 245) solid 1px; padding: 0px; vertical-align: middle;" /><br />
<span style="background-color: inherit; border-bottom: none; border-left: 0px; border-right: 0px; border-top: 0px; box-sizing: border-box; color: inherit; font-style: inherit; font-weight: inherit; margin: 0px; padding: 0px;">If left untreated, malaria can be fatal due to the fast reproduction of the parasite within a host's bloodstream.</span></div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
There are more than 100 types of <em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">Plasmodium</em> parasites,<span style="border: 0px; box-sizing: border-box; color: inherit; font-size: 10px; font-weight: 700; line-height: 0; margin: 0px; padding: 0px 2px 0px 1px; position: relative; top: -0.5em; vertical-align: baseline;">5</span> which can infect a variety of species. Scientists have identified five types that specifically infect humans,<span style="border: 0px; box-sizing: border-box; color: inherit; font-size: 10px; font-weight: 700; line-height: 0; margin: 0px; padding: 0px 2px 0px 1px; position: relative; top: -0.5em; vertical-align: baseline;">6</span> they are:</div>
<ol style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; counter-reset: li 0; font-family: Arial, Helvetica, sans-serif; font-size: 15px; line-height: 22px; list-style: square; margin: 20px 0px 30px 18px; padding: 0px 0px 0px 10px;"><div style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
</div>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px 25px; padding: 0px;"><em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">P. falciparum</em> - located worldwide in tropical and suburban areas, but predominately in Africa. An estimated 1 million people are killed by this strain every year. The strain can multiply rapidly and can adhere to blood vessel walls in the brain, causing rapid onset of severe malaria including cerebral malaria.</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px 25px; padding: 0px;"><em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">P. vivax</em> - located in Latin America, Africa, and Asia, it is arguably the most widespread due to the high population of Asia. This strain has a dormant liver stage that can activate and invade the blood after months or years, causing many patients to relapse.</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px 25px; padding: 0px;"><em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">P. ovale</em> - located mainly in West Africa, it is biologically and morphologically very similar to <em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">P. vivax</em>. However, unlike <em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">P. vivax</em>, this strain can affect individuals who are negative with the Duffy blood group, which is the case for many residents of sub-Saharan Africa. This explains the greater prevalence of <em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">P. ovale</em> (rather than <em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">P. vivax</em>) in most of Africa.</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px 25px; padding: 0px;"><em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">P. malariae</em> - located worldwide and the only human malaria parasite to have a three-day cycle. If left untreated, <em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">P. malariae</em> can cause a long-lasting, chronic infection that can last a lifetime and which may cause the nephrotic syndrome.</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px 25px; padding: 0px;"><em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">P. knowlesi</em> - located in Southeast Asia and associated with macaques (a type of monkey). This strain has a 24 hour cycle and can, therefore, multiply rapidly once a patient is infected, causing an uncomplicated case to become serious very quickly. Fatal cases of infection with this strain have been reported.</li>
</ol>
<h2 style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; clear: both; color: #111111; display: table-cell; font-family: Arial, Helvetica, sans-serif; font-size: 27px; letter-spacing: -1px; line-height: 36px; margin: 30px 0px 20px; padding: 20px 0px 10px; text-shadow: rgb(255, 255, 255) 1px 1px 2px;">
Causes of malaria</h2>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
Malaria is caused by the bites from the female <em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">Anopheles</em> mosquito, which then infects the body with the parasite <em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">Plasmodium</em>. This is the only mosquito that can cause malaria.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
The successful development of the parasite within the mosquito depends on several factors, the most important being humidity and ambient temperatures.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
When an infected mosquito bites a human host, the parasite enters the bloodstream and lays dormant within the liver. For the next 5-16 days, the host will show no symptoms but the malaria parasite will begin multiplying asexually.<span style="border: 0px; box-sizing: border-box; color: inherit; font-size: 10px; font-weight: 700; line-height: 0; margin: 0px; padding: 0px 2px 0px 1px; position: relative; top: -0.5em; vertical-align: baseline;">7</span></div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
The new malaria parasites are then released back into the bloodstream when they infect red blood cells and again begin to multiply. Some malaria parasites, however, remain in the liver and are not released until later, resulting in recurrence.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
An unaffected mosquito becomes infected once it feeds on an infected individual, thus beginning the cycle again.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
The video below from the Howard Hughes Medical Institute visualizes how a single bite from an infected mosquito can quickly turn into the life-threatening disease.</div>
<h2 style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; clear: both; color: #111111; display: table-cell; font-family: Arial, Helvetica, sans-serif; font-size: 27px; letter-spacing: -1px; line-height: 36px; margin: 30px 0px 20px; padding: 20px 0px 10px; text-shadow: rgb(255, 255, 255) 1px 1px 2px;">
Symptoms of malaria</h2>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
According to the Centers for Disease Control and Prevention (CDC), malaria symptoms can be classified in two categories: uncomplicated and severe malaria.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
Uncomplicated malaria is diagnosed when symptoms are present, but there are no clinical or laboratory signs to indicate a severe infection or the dysfunction of vital organs. Individuals suffering from this form, can eventually develop severe malaria if the disease is left untreated, or if they have poor or no immunity to the disease.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
Symptoms of uncomplicated malaria typically last 6-10 hours and occur in cycles that occur every second day, although some strains of the parasite can cause a longer cycle or mixed symptoms. Symptoms are often flu-like and may be undiagnosed or misdiagnosed in areas where malaria is less common. In areas where malaria is common, many patients recognize the symptoms as malaria and treat themselves without proper medical care.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
Uncomplicated malaria typically has the following progression of symptoms through cold, hot and sweating stages:</div>
<ul style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 15px; line-height: 22px; list-style: square; margin: 20px 0px 30px 18px; padding: 0px 0px 0px 10px;">
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px;">Sensation of cold, shivering</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px;">Fever, headaches, and vomiting (seizures sometimes occur in young children)</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px;">Sweats followed by a return to normal temperature, with tiredness.</li>
</ul>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
Severe malaria is defined by clinical or laboratory evidence of vital organ dysfunction. This form has the capacity to be fatal if left untreated. <span style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; font-weight: 600; margin: 0px; padding: 0px;">As a general overview, symptoms of severe malaria include:</span></div>
<ul style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 15px; line-height: 22px; list-style: square; margin: 20px 0px 30px 18px; padding: 0px 0px 0px 10px;">
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px;">Fever and chills</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px;">Impaired consciousness</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px;">Prostration (adopting a prone or prayer position)</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px;">Multiple convulsions</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px;">Deep breathing and respiratory distress</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px;">Abnormal bleeding and signs of anemia</li>
<li style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; line-height: 23px; margin: 0px 0px 10px; padding: 0px;">Clinical jaundice and evidence of vital organ dysfunction.</li>
</ul>
<hr style="background: rgb(255, 255, 255); border-bottom-color: rgb(215, 232, 224); border-bottom-style: solid; border-image: initial; border-left: none; border-right: none; border-top: none; box-sizing: content-box; clear: both; color: #111111; content: ""; display: table; font-family: Arial, Helvetica, sans-serif; font-size: 15px; height: 1px; margin: -1px 0px 20px; padding: 0px; width: 880px;" />
<span class="anchor" id="what_is_malaria" style="background-color: white; border: 0px; box-sizing: border-box; clear: both; color: #111111; display: block; float: left; font-family: "arial" , "helvetica" , sans-serif; font-size: 15px; height: 80px; margin: -80px 0px 0px; padding: 0px; visibility: hidden;"></span><span class="anchor" id="causes_of_malaria" style="background-color: white; border: 0px; box-sizing: border-box; clear: both; color: #111111; display: block; float: left; font-family: "arial" , "helvetica" , sans-serif; font-size: 15px; height: 80px; margin: -80px 0px 0px; padding: 0px; visibility: hidden;"></span><span class="anchor" id="symptoms_of_malaria" style="background-color: white; border: 0px; box-sizing: border-box; clear: both; color: #111111; display: block; float: left; font-family: "arial" , "helvetica" , sans-serif; font-size: 15px; height: 80px; margin: -80px 0px 0px; padding: 0px; visibility: hidden;"></span><br />
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-top: 8px; padding: 0px;">
<span style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; font-weight: 600; margin: 0px; padding: 0px;">On the next page</span>, we will look at the tests, diagnosis and treatments for malaria.</div>
<h2 style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; clear: both; color: #111111; display: table-cell; font-family: Arial, Helvetica, sans-serif; font-size: 27px; letter-spacing: -1px; line-height: 36px; margin: 30px 0px 20px; padding: 20px 0px 10px; text-shadow: rgb(255, 255, 255) 1px 1px 2px;">
Tests and diagnosis of malaria</h2>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-top: 8px; padding: 0px;">
<br style="box-sizing: border-box; font-size: 15px;" />
<span style="font-size: 15px;">Early diagnosis of malaria is critical for a patient's recovery. Any individual showing signs of malaria should be tested immediately. The WHO strongly advise parasitological confirmation by microscopy or a rapid diagnostic test (RDT).</span><span style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; font-size: 10px; font-weight: 700; line-height: 0; margin: 0px; padding: 0px 2px 0px 1px; position: relative; top: -0.5em; vertical-align: baseline;">8</span><span style="font-size: 15px;"></span></div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
The choice of testing method is, of course, dependent on the medical facilities available. RDT has become popular worldwide due to its capacity to provide a quick diagnosis.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
RDTs are increasingly used as health care professionals seek to not only improve testing methodologies, but also to ensure that the opportunity for testing reaches a wider audience. The number of RDTs distributed by national malaria control programs around the world has increased substantially. In 2005, less than 200,000 RDTs were provided, in 2012 this number had risen to 108 million.<span style="border: 0px; box-sizing: border-box; color: inherit; font-size: 10px; font-weight: 700; line-height: 0; margin: 0px; padding: 0px 2px 0px 1px; position: relative; top: -0.5em; vertical-align: baseline;">9</span></div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
The signs and symptoms of the disease are non-specific. However, malaria is clinically suspected on the basis of fever, or a history of fever. Unfortunately, there is no combination of symptoms that can reliably distinguish the disease from other causes, hence the importance of a parasitological test.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
In some malaria-endemic areas, such as sub-Saharan Africa, the disease is so intense that a large proportion of the local population can develop a mild immunity to the disease. As a result, some people can still carry the parasites in their bloodstream, but do not fall ill.</div>
<h2 style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; clear: both; color: #111111; display: table-cell; font-family: Arial, Helvetica, sans-serif; font-size: 27px; letter-spacing: -1px; line-height: 36px; margin: 30px 0px 20px; padding: 20px 0px 10px; text-shadow: rgb(255, 255, 255) 1px 1px 2px;">
Treatments for malaria</h2>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
If left untreated, malaria can be fatal. The aim of treatment is to eliminate the <em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">Plasmodium</em> parasite from the patient's bloodstream. Even those who are asymptomatic may be treated for infection so as to reduce the risk of disease transmission in the general populace.</div>
<div class="photobox_right" style="-webkit-print-color-adjust: exact; background-color: white; border: 1px solid rgb(215, 232, 224); box-sizing: border-box; clear: right; color: #444444; float: right; font-family: Arial, Helvetica, sans-serif; font-size: 0.9em; line-height: 18px; margin: 10px 0px 20px 20px; max-width: 350px; min-width: 100px; outline: 0px; padding: 10px; text-align: center;">
<img alt="Anti-malaria drugs can now be obtained by healthcare services." data-src="http://cdn1.medicalnewstoday.com/content/images/articles/150/150670/anti-malaria-drugs-can-now-be-obtained-by-healthcare-services.jpg" src="https://cdn1.medicalnewstoday.com/content/images/articles/150/150670/anti-malaria-drugs-can-now-be-obtained-by-healthcare-services.jpg" style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; float: none; height: auto; margin: 0px auto 5px; max-width: 100%; outline: rgb(245, 245, 245) solid 1px; padding: 0px; vertical-align: middle;" /><br />
<span style="background-color: inherit; border-bottom: none; border-left: 0px; border-right: 0px; border-top: 0px; box-sizing: border-box; color: inherit; font-style: inherit; font-weight: inherit; margin: 0px; padding: 0px;">Anti-malaria drugs are more accessible than ever before, but further challenges lie ahead until the disease is eradicated.</span></div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
Artemisinin-based combination therapy (ACT) is recommended by the WHO to treat uncomplicated malaria. Artemisinin is derived from the plant <em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">Artemisia annua</em>, better known as sweet wormwood, and is known for its ability to reduce quickly the number of <em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">Plasmodium</em> parasites in the bloodstream.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
<span style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; font-weight: 600; margin: 0px; padding: 0px;">ACT is artemisinin combined with a partner drug. The role of artemisinin is to reduce the number of parasites within the first three days while the partner drugs eliminate the rest.</span></div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
Expanding the access to ACTs has been integral to the global fight against the disease. In 2013, 392 million ACT treatment courses were obtained by endemic countries, a substantial rise from 11 million in 2005.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
However, there is growing concern about the increase of cases of malaria resistant to the effects of ACTs. As of February 2015, artemisinin resistance has been confirmed in five countries: Cambodia, Laos, Myanmar, Thailand and Vietnam. For these cases, individuals were still successfully treated, but the ACT must contain an effective partner drug.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
The WHO has warned that as no alternatives to artemisinin are likely to become available for several years, and because ACTs are the main treatment for <em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">P. falciparum</em> malaria, it is of paramount importance that steps be taken to prevent the spread of ACT-resistant strains. National malaria control programs are now being asked to regularly monitor the efficacy of antimalarial medicines in use to ensure that treatments remain efficacious.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
<em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">Medical News Today</em> recently reported a new study that revealed a breakthrough for scientists <a href="http://www.medicalnewstoday.com/articles/296994.php" style="-webkit-print-color-adjust: exact; background-color: transparent; border-bottom: none; border-image: initial; border-left: 0px; border-right: 0px; border-top: 0px; box-sizing: border-box; color: #b000b5; font-weight: 600; margin: 0px; outline: 0px; padding: 0px;">overcoming the Artemisinin resistance</a>.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
Furthermore, there has been cases of fake anti-malaria drugs being distributed, the majority of these were found in Africa. In response, The US Food and Drug Administration announced <a href="http://antimalariatablets.blogspot.co.uk/" style="-webkit-print-color-adjust: exact; background-color: transparent; border-bottom: none; border-image: initial; border-left: 0px; border-right: 0px; border-top: 0px; box-sizing: border-box; color: #b000b5; font-weight: 600; margin: 0px; outline: 0px; padding: 0px;">a handheld device to identify counterfeit medicines</a>.</div>
<h2 style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; clear: both; color: #111111; display: table-cell; font-family: Arial, Helvetica, sans-serif; font-size: 27px; letter-spacing: -1px; line-height: 36px; margin: 30px 0px 20px; padding: 20px 0px 10px; text-shadow: rgb(255, 255, 255) 1px 1px 2px;">
Vaccines for malaria</h2>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
<span style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; font-weight: 600; margin: 0px; padding: 0px;">Research is ongoing to develop safe and effective vaccines for malaria, with one vaccine close to being licensed for use in Europe.</span></div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
The development of an effective malaria vaccine poses major challenges as a comprehensive vaccine would need to be effective against a number of strains of malaria parasites. As such, the majority of vaccines in development are focused on the most serious and deadly parasite, <em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">Plasmodium falciparum</em>. The development of a vaccine against <em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">P. vivax</em> is complicated by the associated relapses and hypnozoite stages of infection with this parasite.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
The malaria vaccine that may soon be approved for use in humans is called RTS,S/AS01 and was developed through a partnership between GlaxoSmithKline Biologicals (GSK) and the PATH Malaria Vaccine Initiative (MVI), with support from the Bill & Melinda Gates Foundation.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
This vaccine has completed Phase III testing and, in 2015, the European Medicines Agency (EMA) issued "a European scientific opinion" that indicated that they had assessed the vaccine as favourable in terms of its risk/benefit from a regulatory perspective. Although the vaccine is not licensed or approved for use in Europe, this statement may help regulatory authorities in Africa reach a decision on licensure.<span style="border: 0px; box-sizing: border-box; color: inherit; font-size: 10px; font-weight: 700; line-height: 0; margin: 0px; padding: 0px 2px 0px 1px; position: relative; top: -0.5em; vertical-align: baseline;">11</span></div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
This vaccine is effective against <em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">P. falciparum</em> only; it affords no protection against <em style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; margin: 0px; padding: 0px;">P. vivax</em> malaria.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
The malaria vaccine has been tested for efficacy in 5-17 month old children and 6-12 week old infants. Researchers found that the vaccine was 39% effective in the older children who received four doses on a 0, 1, 2, 20 month schedule. The vaccine was 31.5% effective against severe malaria in these 5-17 month old children, but no protection was conferred against severe <a href="http://antimalariatablets.blogspot.co.uk/" target="_blank">malaria</a> if children did not receive the fourth dose.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
In the younger infants (6-12 weeks), the vaccine was 27% effective when the first three doses were given at 6, 10 and 14 weeks of age, and a fourth dose 18 months later. The vaccine was 18% effective in the children who did not receive the fourth dose. The vaccine was not seen to be effective against severe malaria in this age group, however.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
Testing revealed some unexplained phenomenon in those children receiving the vaccine, including an increase in febrile seizures, meningitis and cerebral malaria. It is not yet known if these issues are related to the vaccine itself or are due to some other cause.</div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-top: 8px; padding: 0px;">
<span class="anchor" id="treatments_for_malaria" style="-webkit-print-color-adjust: exact; border: 0px; box-sizing: border-box; clear: both; display: block; float: left; font-size: 15px; height: 80px; margin: -80px 0px 0px; padding: 0px; visibility: hidden;"></span></div>
<div style="-webkit-print-color-adjust: exact; background-color: white; border: 0px; box-sizing: border-box; color: #111111; font-family: Arial, Helvetica, sans-serif; font-size: 16px; line-height: 24px; margin-bottom: 16px; margin-top: 8px; padding: 0px;">
Approval of RTS,S/AS01 in Europe represents the first approval of a vaccine for a disease caused by parasites; all other vaccines are for use against diseases caused by either viruses or bacteria</div>
Anonymoushttp://www.blogger.com/profile/05896487553262689465noreply@blogger.com0